I'd check carb balance, and tickover speed are correct first. Then make sure all four sparkplugs are screwed in. One loose makes a very hard to find noise which I remember frightening my wallet when it happened to me.
In my case it was the front deeply buried one, which had worked it's way out of the thread due to my fear of overtightening and stripping a thread I can't see.
3 Africa Twins/280,000 miles. If it's happened to one of mine, it's gonna happen to one of yours.....eventually.
1 Varadero/17,000 miles ridden (of 40,000 miles on the bike), it's all still new to me!
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