Try altering where you sit on the saddle (slide forwards and backwards). Most importantly, think about your posture. Too many riders slouch in the saddle. Sit with your back straight, your body-weight distributed between butt, feet and hands, your hips rolled forwards, and your "tail" (coccyx) pointing towards the rear light not the footrests. It might feel a little unnatural at first, but if you persevere, you'll find that the air flows more cleanly, you can reach the bars more easily, you won't ache so much, and you'll avoid damaging your spine.
Move your body from time to time. Holding one motionless position will cause a build-up of lactic acid that makes muscles ache. This can be dispersed simply by moving your head when you look in the mirror, occasionally moving your shoulders and arms, wiggling your toes and so on.
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